Protection induced by malaria virus-like particles containing codon-optimized AMA-1 of Plasmodium berghei
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چکیده
منابع مشابه
The Effects of Splenectomy on Pattern of Nitric Oxide Induction and Pathogenesis of Rodent Malaria Caused by Plasmodium berghei Infection
Background and Aims: The aim of this study is to clarify nitric oxide (NO)-production by spleen and the importance of spleen in malaria infection in murine model. Materials and Methods: Thirty outbred NMRI female mice were divided into four groups, Group I: No intervention (Healthy control), Group II: With splenectomy (Healthy test), Group III: No intervention, Inoculation of contaminated bloo...
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With the aim to develop an efficient and cost-effective approach to control malaria, we have generated porcine parvovirus-like particles (PPV-VLPs) carrying the CD8(+) T cell epitope (SYVPSAEQI) of the circumsporozoite (CS) protein from Plasmodium yoelii fused to the PPV VP2 capsid protein (PPV-PYCS), and tested in prime/boost protocols with poxvirus vectors for efficacy in a rodent malaria mod...
متن کاملThe Exported Protein PbCP1 Localises to Cleft-Like Structures in the Rodent Malaria Parasite Plasmodium berghei
Protein export into the host red blood cell is one of the key processes in the pathobiology of the malaria parasite Plasmodiumtrl falciparum, which extensively remodels the red blood cell to ensure its virulence and survival. In this study, we aimed to shed further light on the protein export mechanisms in the rodent malaria parasite P. berghei and provide further proof of the conserved nature ...
متن کامل-Kit in Malaria Transmission Studies Using Plasmodium Berghei
Pre-clinical transmission assays are essential for proof-of-concept for transmission blocking strategies but are hazardous to laboratory personnel and animal hosts as it entails exposure of live rodents to infected vectors. Conventional transmission assay methods include the use of anesthesia (associated with undesired side effects). In addition, animal handlers risk being bitten by experimenta...
متن کاملRegional immunosuppression induced by Plasmodium berghei yoelii infection in mice.
Plasmodium berghei yoelii infection in mice severely depressed the splenic antibody response to sheep erythrocytes but had lettle effect on antibody formation in lymph nodes.
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2019
ISSN: 1475-2875
DOI: 10.1186/s12936-019-3017-2